| dc.contributor.advisor |
Kafka, Stanislav
|
|
| dc.contributor.author |
Marcin, Tomáš
|
|
| dc.date.accessioned |
2010-07-19T04:47:23Z |
|
| dc.date.available |
2010-07-19T04:47:23Z |
|
| dc.date.issued |
2010-06-01 |
|
| dc.identifier |
Elektronický archiv Knihovny UTB |
cs |
| dc.identifier.uri |
http://hdl.handle.net/10563/11901
|
|
| dc.description.abstract |
Byly připraveny 3-ethyl-3-halogenchinolin-2,4(1H,3H)-diony 2, 3 a 4a-e reakcemi odpovídajících 3-substituovaných 4-hydroxychinolin-2(1H)-onů 1a-e s halogenačními či-nidly. Sloučeniny 4a-e připravené reakcí substrátů s Lugolovým roztokem v zásaditém prostředí jsou prvními reprezentanty 3-jodchinolin-2,4(1H,3H)-dionů. 3-Fenyl-4-hydroxy-6-methoxychinolin-2(1H)-on s Lugolovým roztokem za podmínek, při kterých byly při-praveny jodderiváty 4a-e, nereaguje. Byly provedeny pokusy pro porovnání reaktivity tří 3-ethyl-3-halogenchinolin-2,4(1H,3H)-dionů (2, 3, a 4a) lišících se atomem halogenu s azidem sodným v dimethylformamidu, které potvrdily očekávání, že jejich reaktivita se zvyšuje v uvedeném pořadí. Reakcí sloučeniny 4a s naftalen-2-aminem vznikl 3-ethyl-3-hydroxychinolin-2,4(1H,3H)-dion (6) vedle neidentifikovaného produktu. Chlorderivát 2 se reakcí se semikarbazidem v benzenu při pokojové teplotě během 78 hodin jen zčásti přeměnil na hydroxychinolon 1a, zatímco přeměna jodderivátu 4a na sloučeninu 1a pro-běhla úplně během 20 minut v ledové lázni za jinak stejných podmínek; při žádném z obou pokusů nebyl indikován vznik produktu substituce atomu halogenu dusíkatou skupinou. |
cs |
| dc.format |
34 |
cs |
| dc.format.extent |
1388661 bytes |
cs |
| dc.format.mimetype |
application/pdf |
cs |
| dc.language.iso |
cs |
|
| dc.publisher |
Univerzita Tomáše Bati ve Zlíně |
|
| dc.rights |
Bez omezení |
|
| dc.subject |
3-substituovaný 3-halogenchinolin-2
|
cs |
| dc.subject |
4
|
cs |
| dc.subject |
1H
|
cs |
| dc.subject |
3H-dion
|
cs |
| dc.subject |
reaktivita
|
cs |
| dc.subject |
vliv substituce
|
cs |
| dc.subject |
3-ethyl-3-jodchinolin-2
|
cs |
| dc.subject |
4
|
cs |
| dc.subject |
1H
|
cs |
| dc.subject |
3H-dion
|
cs |
| dc.subject |
2-naftylamin
|
cs |
| dc.subject |
semikarbazid
|
cs |
| dc.subject |
3-substituted 3-halogenoquinoline-2
|
en |
| dc.subject |
4
|
en |
| dc.subject |
1H
|
en |
| dc.subject |
3H-dione
|
en |
| dc.subject |
reactivity
|
en |
| dc.subject |
substitution effect
|
en |
| dc.subject |
3-ethyl-3-iodoquinoline-2
|
en |
| dc.subject |
4
|
en |
| dc.subject |
1H
|
en |
| dc.subject |
3H-dione
|
en |
| dc.subject |
2-naphthylamine
|
en |
| dc.subject |
semicarbazide
|
en |
| dc.title |
Studium reakcí 3-halogenchinolin-2,4(1H,3H)-dionů s vybranými reaktanty |
cs |
| dc.title.alternative |
Investigation of the reactions of 3-halogenoquinoline-2,4(1H,3H)-diones with selected reactants |
en |
| dc.type |
bakalářská práce |
cs |
| dc.contributor.referee |
Klásek, Antonín |
|
| dc.date.accepted |
2010-06-07 |
|
| dc.description.abstract-translated |
3-Ethyl-3-halogenquinoline-2,4(1H,3H)-diones 2, 3 and 4a-e were prepared by the reactions of 3-substituted 4-hydroxyquinolin-2(1H)-ones 1a-e with halogenating agents. Compounds 4a-e prepared by the reaction of the substrates with Lugol's solution in basic medium are the first representatives of 3-iodoquinoline-2,4(1H,3H)-diones. 3-Phenyl-4-hydroxy-6-methoxyquinolin-2(1H)-on did not reacted with Lugol's solution under conditi-ons applied for the preparation of iododerivatives 4a-e. The experiments for the compa-ration of the reactivity of three 3-ethyl-3-halogenoquinoline-2,4(1H,3H)-diones, containing different halogen atoms, with sodium azide confirmed the expectation that the reactivity of them increases in the given order. By the reaction of compound 4a with naphthalen-2-amine, 3-ethyl-3-hydroxyquinoline-2,4(1H,3H)-dione (6) was formed together with an unidentified product. The chloroderivative 2 treated with semicarbazide in benzene at room temperature for 78 hours was only partially converted to hydroxyquinolone 1a, whereas the conversion of iododerivatives 4a to compound 1a was completed during 20 minutes in ice bath under the same conditions. The formation of any product of the substitution of halogen atom with nitrogen containing substituent was indicated in no of both last mentio-ned experiments. |
en |
| dc.description.department |
Ústav technologie a mikrobiologie potravin |
cs |
| dc.description.result |
obhájeno |
cs |
| dc.parent.uri |
http://hdl.handle.net/10563/144
|
cs |
| dc.parent.uri |
http://hdl.handle.net/10563/220
|
cs |
| dc.thesis.degree-discipline |
Chemie a technologie potravin |
cs |
| dc.thesis.degree-discipline |
Chemistry and food technologies |
en |
| dc.thesis.degree-grantor |
Univerzita Tomáše Bati ve Zlíně. Fakulta technologická |
cs |
| dc.thesis.degree-grantor |
Tomas Bata University in Zlín. Faculty of Technology |
en |
| dc.thesis.degree-name |
Bc. |
cs |
| dc.thesis.degree-program |
Chemie a technologie potravin |
cs |
| dc.thesis.degree-program |
Chemistry and food technologies |
en |
| dc.identifier.stag |
16165
|
|
| dc.date.assigned |
2010-02-11 |
|
| utb.result.grade |
C |
|
