| dc.contributor.advisor |
Kafka, Stanislav
|
|
| dc.contributor.author |
Hoffmannová, Petra
|
|
| dc.date.accessioned |
2023-12-20T13:25:09Z |
|
| dc.date.available |
2023-12-20T13:25:09Z |
|
| dc.date.issued |
2022-12-31 |
|
| dc.identifier |
Elektronický archiv Knihovny UTB |
|
| dc.identifier.uri |
http://hdl.handle.net/10563/53844
|
|
| dc.description.abstract |
Reakcí primárních aromatických aminů s methylketony a kyanovodíkem byly připraveny alfa-aminonitrily 1. Eliminací kyanovodíku byly alfa-aminonitrily 1 převedeny na iminy (anily) 2, které byly podrobeny kondenzaci s bis-(2,4,6-trichlorfenyl)estery kyseliny malonové za vzniku derivátů 4-hydroxypyridin-2(1H)-onů 3. Kondenzace byly provedeny jednak konvenční metodou A, jednak metodou asistovanou mikrovlnami B. Kondenzací iminu 2c s bis-(2,4,6-trichlorfenyl)-2-butylmalonátem 6a byl získán v závislosti na původu esteru 6a buď 3-butyl-4-hydroxy-1-(3-methoxyfenyl)-6-fenylpyridin-2(1H)-on 3b nebo 3-butyl-4-hydroxy-7-methoxychinolin-2(1H)-on 4b. Kondenzace iminu 2e s bis-(2,4,6-trichlorfenyl)-2-ethylmalonátem poskytla směs 1-(3,5-dimethylfenyl)-3-ethyl-4-hydroxy-6-fenylpyridin-2(1H)-onu 3g a 3-ethyl-4-hydroxy-5,7-dimethylchinolin-2(1H)-onu 4g. |
|
| dc.format |
62 s. (77 974 znaků) |
|
| dc.language.iso |
cs |
|
| dc.publisher |
Univerzita Tomáše Bati ve Zlíně |
|
| dc.rights |
Bez omezení |
|
| dc.subject |
syntéza
|
cs |
| dc.subject |
alfa-aminonitril
|
cs |
| dc.subject |
imin
|
cs |
| dc.subject |
4-hydroxypyridin-2
|
cs |
| dc.subject |
1H
|
cs |
| dc.subject |
-on
|
cs |
| dc.subject |
bis-
|
cs |
| dc.subject |
2
|
cs |
| dc.subject |
4
|
cs |
| dc.subject |
6-trichlorfenyl
|
cs |
| dc.subject |
malonáty
|
cs |
| dc.subject |
synthesis
|
en |
| dc.subject |
alpha-aminonitrile
|
en |
| dc.subject |
imine
|
en |
| dc.subject |
4-hydroxypyridine-2
|
en |
| dc.subject |
1H
|
en |
| dc.subject |
-one
|
en |
| dc.subject |
bis-
|
en |
| dc.subject |
2
|
en |
| dc.subject |
4
|
en |
| dc.subject |
6-trichlorophenyl
|
en |
| dc.subject |
malonate
|
en |
| dc.title |
Syntézy 4-hydroxypyridin-2-onů s využitím alfa-aminonitrilů |
|
| dc.title.alternative |
Syntheses of 4-hydroxypyridin-2-ones Using Alfa-aminonitriles |
|
| dc.type |
diplomová práce |
cs |
| dc.contributor.referee |
Potáček, Milan |
|
| dc.date.accepted |
2023-06-08 |
|
| dc.description.abstract-translated |
By the reaction of aromatic amines with methylketones and hydrogen cyanide were prepared alpha-aminonitriles 1. By elimination of hydrogen cyanide were alpha-aminonitriles 2 transformed to imines, which were subjected to condensation with bis-(2,4,6-trichlorophenyl)esters of malonic acid to form 4-hydroxypyridin-2(1H)-one derivates 3. Condensations were provided by two methods, convinient method A and microwave method B. By condensation of imine 2c with bis-(2,4,6-trichlorophenyl)-2-butylmalonate 6a was obtained corresponding 3-butyl-4-hydroxy-1-(3-methoxyphenyl)-6-phenylpyridine-2(1H)-one 3b or 3-butyl-4-hydroxy-7-methoxychinoline-2(1H)-one 4b. By condensation of imine 2e with bis-(2,4,6-trichlorophenyl)-2-ethylmalonate was obtained mixture of 1-(3,5-dimethylphenyl)-3-ethyl-4-hydroxy-6-phenylpyridine-2(1H)-one 3g a 3-ethyl-4-hydroxy-5,7-dimethylchinoline-2(1H)-one 4g. |
|
| dc.description.department |
Ústav chemie |
|
| dc.thesis.degree-discipline |
- |
cs |
| dc.thesis.degree-grantor |
Univerzita Tomáše Bati ve Zlíně. Fakulta technologická |
cs |
| dc.thesis.degree-grantor |
Tomas Bata University in Zlín. Faculty of Technology |
en |
| dc.thesis.degree-name |
Ing. |
|
| dc.thesis.degree-program |
Chemie potravin a bioaktivních látek |
cs |
| dc.thesis.degree-program |
Chemistry of Food and Bioactive Compounds |
en |
| dc.identifier.stag |
64604
|
|
| dc.date.submitted |
2023-05-12 |
|
