| dc.contributor.advisor |
Kafka, Stanislav
|
|
| dc.contributor.author |
Kaloda, Pavel
|
|
| dc.date.accessioned |
2019-07-04T09:11:30Z |
|
| dc.date.available |
2019-07-04T09:11:30Z |
|
| dc.date.issued |
2019-02-01 |
|
| dc.identifier |
Elektronický archiv Knihovny UTB |
|
| dc.identifier.uri |
http://hdl.handle.net/10563/45526
|
|
| dc.description.abstract |
Reakcí N-substituovaných anilinů s chloracetylchloridem nebo s bromacetylbromidem byly připraveny odpovídající a-bromacetanilidy resp. a-chloracetanilidy. Halogenacetanilidy byly podrobeny reakcí s trifenylfosfinem, a byly tak převedeny na odpovídající fosfoniové soli. V. Eliminací bromovodíku z (2-amino-2-oxoethyl)trifenylfosfonium bromidů disubstituovaných na atomu dusíku účinkem triethylaminu byly připraveny odpovídající N,N-disubstituované 2-(trifenyl?fosforan-yliden)acetamidy. Fosfoniová sůl s atomem vodíku na atomu dusíku při pokusech o eliminaci bromovodíku za různých podmínek buď nereagovala, nebo se rozložila na acetanilid a trifenylfosfinoxid. S N,N-difenyl-2-(trifenylfosforanyliden)acetamidem byl proveden pokus o Wittigovy reakce s diethyl-karbonátem, avšak očekávaný 3,3-diethoxy-N,N-difenylakrylamid nebyl získán. Reakcí sloučeniny N,N-difenyl-2-(trifenylfosforanyliden)acetamidem s 3-butyl-3-hydroxy-1-methylchinolin-2,4(1H,3H)-dionem byl připraven 3a-butyl-5-methylfuro[2,3-c]chinolin-2,4(3H,5H)-dion (IX). |
|
| dc.format |
61 s. |
|
| dc.language.iso |
cs |
|
| dc.publisher |
Univerzita Tomáše Bati ve Zlíně |
|
| dc.rights |
Bez omezení |
|
| dc.subject |
syntéza
|
cs |
| dc.subject |
a-halogenacetanilid
|
cs |
| dc.subject |
fosfoniová sůl
|
cs |
| dc.subject |
2-
|
cs |
| dc.subject |
trifenylfosforanyliden
|
cs |
| dc.subject |
acetamid
|
cs |
| dc.subject |
chinolin-2
|
cs |
| dc.subject |
4
|
cs |
| dc.subject |
1H
|
cs |
| dc.subject |
3H
|
cs |
| dc.subject |
-dion
|
cs |
| dc.subject |
synthesis
|
en |
| dc.subject |
a-haloacetanilide
|
en |
| dc.subject |
phosphonium salt
|
en |
| dc.subject |
phosphoranylidene
|
en |
| dc.subject |
quinolone-2
|
en |
| dc.subject |
4-2
|
en |
| dc.subject |
4
|
en |
| dc.subject |
1H
|
en |
| dc.subject |
3H
|
en |
| dc.subject |
-diones
|
en |
| dc.subject |
4-hydroxyquinolines
|
en |
| dc.title |
Studium využití N-fenyl-2-(trifenylfosforanyliden)acetamidu k syntéze derivátů chinolin-2-onu |
|
| dc.title.alternative |
Study of the Use of N-phenyl-2-(triphenylphosphoranylidene)acetamide for the Synthesis of Quinolin-2-one Derivatives |
|
| dc.type |
diplomová práce |
cs |
| dc.contributor.referee |
Klásek, Antonín |
|
| dc.date.accepted |
2019-06-12 |
|
| dc.description.abstract-translated |
By reacting N-substituted anilines with chloroacetyl chloride or bromoacetyl bromide desired a-bromoacetanilides and a-chloroacetanilides were prepared. The haloacetanilides reacted with triphenylphosphine and were converted to the corresponding phosphonium salts. Elimination of hydrogen bromide from (2-amino 2-oxoethyl)triphenylphosphonium bromides disubstituted by the nitrogen atom were prepared by effect of triethylamine to give corresponding N,N-disubstituted 2-(triphenylphosphoraneylidene)acetamides. In various attempts to eliminate hydrogen bromide hydrogen atom located on the nitrogen atom of phosphonium salt did not react or compounds decomposed to acetanilide and triphenylphosphine oxide. N,N-diphenyl-2-(triphenylphosphoranylidene)acetamide was subjected to Wittig reaction with diethyl carbonate but the expected 3,3 diethoxy N,N diphenylacrylamide was not obtained. Reaction of N,N-diphenyl-2-(triphenylphosphoranylidene)acetamide with 3-butyl-3-hydroxy-1-methylquinoline-2,4(1H,3H)-dione gave 3-butyl-5-methylfuro[2,3-c]quinoline-2,4-(3H,5H)-dione. |
|
| dc.description.department |
Ústav chemie |
|
| dc.thesis.degree-discipline |
Chemie potravin a bioaktivních látek |
cs |
| dc.thesis.degree-discipline |
Food Chemistry and Chemistry of Bioactive Substances |
en |
| dc.thesis.degree-grantor |
Univerzita Tomáše Bati ve Zlíně. Fakulta technologická |
cs |
| dc.thesis.degree-grantor |
Tomas Bata University in Zlín. Faculty of Technology |
en |
| dc.thesis.degree-name |
Ing. |
|
| dc.thesis.degree-program |
Chemie a technologie potravin |
cs |
| dc.thesis.degree-program |
Chemistry and Food Technologies |
en |
| dc.identifier.stag |
53219
|
|
| utb.result.grade |
C |
|
| dc.date.submitted |
2019-05-24 |
|
