| dc.contributor.advisor |
Kafka, Stanislav
|
|
| dc.contributor.author |
Kapavíková, Iveta
|
|
| dc.date.accessioned |
2015-03-08T21:14:09Z |
|
| dc.date.available |
2015-03-08T21:14:09Z |
|
| dc.date.issued |
2014-02-07 |
|
| dc.identifier |
Elektronický archiv Knihovny UTB |
|
| dc.identifier.uri |
http://hdl.handle.net/10563/29746
|
|
| dc.description.abstract |
Reakcí 3-substituovaných 3-chlorchinolin-2,4(1H,3H)-dionů 2a-d s propargylaminem byla připravena série čtyř 3-propargylaminochinolin-2,4(1H,3H)-dionů 3a-d. Známými reakcemi byly připraveny (azidomethyl)benzen (4) a azidobenzen (5). U těchto azidosloučenin byla vyzkoušena tvorba známých derivátů 1H-1,2,3-triazolu 6a,b a 7a,b reakcemi s fenylacetylenem a s propargylalkoholem v dimethylformamidu za katalýzy sloučeninami CuI generovaným in situ z pentahydrátu síranu měďnatého a mědi. Tento postup byl pak aplikován na reakce 3-propargylaminochinolin-2,4(1H,3H)-dionů 3a d s azidosloučeninami 4 a 5, kterými bylo připraveno 7 látek, z nichž u čtyř (8b,d a 8a,d) bylo pomocí HRMS prokázáno složení očekávaných sloučenin s chinolindionovou a triazolovou částí v molekule, v jednom případě (8b) navíc i elementární analýzou, a u dvou z uvedených čtyř sloučenin (8b,d) byla pomocí NMR spekter potvrzena očekávaná struktura. |
|
| dc.format |
50 |
|
| dc.language.iso |
cs |
|
| dc.publisher |
Univerzita Tomáše Bati ve Zlíně |
|
| dc.rights |
Bez omezení |
|
| dc.subject |
syntéza
|
cs |
| dc.subject |
chinolin-2
|
cs |
| dc.subject |
4
|
cs |
| dc.subject |
1H
|
cs |
| dc.subject |
3H
|
cs |
| dc.subject |
-diony
|
cs |
| dc.subject |
propargylaminosloučeniny
|
cs |
| dc.subject |
azidosloučeniny
|
cs |
| dc.subject |
1
|
cs |
| dc.subject |
3-dipolární adice
|
cs |
| dc.subject |
1H-1
|
cs |
| dc.subject |
2
|
cs |
| dc.subject |
3-triazoly
|
cs |
| dc.subject |
synthesis
|
en |
| dc.subject |
quinoline-2
|
en |
| dc.subject |
4
|
en |
| dc.subject |
1H
|
en |
| dc.subject |
3H
|
en |
| dc.subject |
-diones
|
en |
| dc.subject |
propargylaminocompounds
|
en |
| dc.subject |
azidocompounds
|
en |
| dc.subject |
1
|
en |
| dc.subject |
3-dipolar additions
|
en |
| dc.subject |
1H-1
|
en |
| dc.subject |
2
|
en |
| dc.subject |
3-triazoles
|
en |
| dc.title |
Syntézy chinolin-2,4(1H,3H)-dionů s propargylovou skupinou a jejich reakce s azidosloučeninami |
|
| dc.title.alternative |
Syntheses of Quinoline-2,4(1H,3H)-diones with Propargyl Group and Their Reactions with Azidocompounds |
|
| dc.type |
diplomová práce |
cs |
| dc.contributor.referee |
Potáček, Milan |
|
| dc.date.accepted |
2014-06-10 |
|
| dc.description.abstract-translated |
A series of four 3-propargylaminoquinoline-2,4(1H,3H)-diones 3a-d was prepared by the reaction of 3-substituted 3-chloroquinoline-2,4(1H,3H)-diones 2a-d with propargylamine. (Azidomethyl)benzene (4) and azidobenzene (5) were prepared by the known reactions. These were tested in Cu(I)-catalysed 1H-1,2,3-triazole formation with phenylacetylene and propargyl alcohol as reaction partners and dimethylformamide as a reaction solvent. Cu(I) catalyst was generated in situ from copper(II) sulfate pentahydrate and copper turnings. This procedure was then applied to the reactions of 3-propargylaminoquinoline-2,4(1H,3H)-diones 3a d with azides 4 and 5. Seven new products were prepared; the composition of four of them (8b,d and 8a,d) was confirmed by HRMS. In one case (8b) the composition was corroborated by elemental analysis, and for two compounds (8b,d) the expected structure was confirmed by NMR. |
|
| dc.description.department |
Ústav chemie |
|
| dc.thesis.degree-discipline |
Chemie potravin a bioaktivních látek |
cs |
| dc.thesis.degree-discipline |
Food Chemistry and Chemistry of Bioactive Substances |
en |
| dc.thesis.degree-grantor |
Univerzita Tomáše Bati ve Zlíně. Fakulta technologická |
cs |
| dc.thesis.degree-grantor |
Tomas Bata University in Zlín. Faculty of Technology |
en |
| dc.thesis.degree-name |
Ing. |
|
| dc.thesis.degree-program |
Chemie a technologie potravin |
cs |
| dc.thesis.degree-program |
Chemistry and Food Technologies |
en |
| dc.identifier.stag |
35931
|
|
| utb.result.grade |
B |
|
| dc.date.submitted |
2014-05-12 |
|
